|
KMID : 0982820040030020109
|
|
Journal of Lung Cancer
2004 Volume.3 No. 2 p.109 ~ p.112
|
|
|
Comparison between ＜60 Gy and ≥60 Gy Once-Daily Thoracic Irradiation for Patients with Limited-stage Small- cell Lung Cancer
|
|
Kwon Byung-Hyun
Ki Young-Kan
Kim Dong-Won
Kim Won-Taek
|
|
|
Abstract
|
|
|
Purpose: To review the treatment outcomes of patients with limited-stage small-cell lung cancer (LS-SCLC) receiving daily thoracic irradiation (RT) to ≥ 60 Gy.
Materials and Methods: The records of patients treated with RT for LS-SCLC between 1990 and 2002 at Pusan National University Hospital were retrospectively reviewed. Fifty-six patients were identified who had received once-daily 1.8∼2 Gy fractions from 40 Gy to 63 Gy. All patients received sequential chemotherapy and then RT. These patients were arbitrary divided two groups according to thoracic radiation dose, ＜60 Gy and ≥60 Gy. The time to death was assessed using actuarial method.
Results: Two- and 5-year overall survival rates for ＜60 Gy and ≥60 Gy group was 32% and 41% and 14% and 21%, respectively (p=1.6). Median overall survival for ＜60 Gy group and ≥60 Gy group was 17 and 20 months, respectively. Two case of acute Grade 3 esophagitis and one case of acute Grade 4 pneumonitis developed in ≥60 Gy group. The first relapse sites of chest for ＜60 Gy group and ≥60 Gy group were 9/15 (60%) and 3/8 (38%), respectively (p=0.4).
Conclusion: ≥60 Gy once-daily thoracic radiotherapy was generally well tolerated and moderately improves local control compared to ＜60 Gy in patients with LS_ SCLC who are treated with combination chemotherapy.
|
|
|
KEYWORD
|
|
|
Small-cell lung cancer, Radiotherapy, Chemotherapy, Chemoradiotherapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|